From: bigvince on
On May 26, 1:46 am, "john" <nos...(a)bt.com> wrote:
> FOR IMMEDIATE RELEASE
> Orthomolecular Medicine News Service, May 25, 2010
>
> Vitamin E Research Ignored by Major News Media
> Coast-to-Coast Censorship
> (OMNS, May 25, 2010) If you think Medline and Wikipedia are biased, take a
> look through your newspapers and magazines. For example, have you noticed
> how the news media are quick to publish negative allegations about vitamin
> E, but slow to present the positive side?
>

Great info I found this abstract particuliarly interesting

N Engl J Med. 2010 May 6;362(18):1675-85. Epub 2010 Apr 28.
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.

Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM,
Neuschwander-Tetri BA, Lavine JE, Tonascia J, Unalp A, Van Natta M,
Clark J, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR; NASH CRN.
Collaborators (110)
Lavine J, Sanyal A, Abrams S, Bass N, Chalasani N, Diehl AM, Kowdley
K, Loomba R, McCullough A, Molleston J, Murray K, Robuck P, Rosenthal
P, Neuschwander-Tetri B, Tonascia J, Chalasani N, Sanyal A, Unalp A,
McCullough A, Bringman D, Dasarathy S, Edwards K, Hawkins C, Liu YC,
Rogers N, Sargent R, Diehl AM, Abdelmalek M, Gottfried M, Guy C,
Killenberg P, Kwan S, Pan YP, Piercy D, Smith M, Chalasani N, Bhimalli
P, Cummings OW, Klipsch A, Lee L, Molleston J, Ragozzino L,
Vuppalanchi R, Neuschwander-Tetri BA, Derdoy J, Hoffmann J, King D,
Siegner J, Stewart S, Thompson J, Brunt E, Lavine JE, Behling C, Clark
L, Durelle J, Hassanein T, Petcharaporn L, Schwimmer JB, Sirlin C,
Stein T, Bass NM, Bambha K, Ferrell LD, Filipowski D, Merriman R,
Pabst M, Rosenthal M, Rosenthal P, Steel T, Sanyal AJ, Boyett S,
Contos MJ, Fuchs M, Jones A, Luketic VA, Sandhu B, Sargeant C, Selph
K, White M, Kowdley KV, Gyurkey G, Mooney J, Nelson J, Ackermann S,
Saunders C, Stead A, Wang C, Yeh M, Kleiner D, Doo E, Everhart J,
Hoofnagle JH, Robuck PR, Seeff L, Tonascia J, Belt P, Brancati F,
Clark J, Colvin R, Donithan M, Green M, Isaacson M, Kim W, Miriel L,
Sternberg A, Unalp A, Van Natta M, Vaughn I, Wilson L, Yates K.

Virginia Commonwealth University, Richmond, USA. asanyal(a)mcvh-vcu.edu
Abstract

BACKGROUND: Nonalcoholic steatohepatitis is a common liver disease
that can progress to cirrhosis. Currently, there is no established
treatment for this disease. METHODS: We randomly assigned 247 adults
with nonalcoholic steatohepatitis and without diabetes to receive
pioglitazone at a dose of 30 mg daily (80 subjects), vitamin E at a
dose of 800 IU daily (84 subjects), or placebo (83 subjects), for 96
weeks. The primary outcome was an improvement in histologic features
of nonalcoholic steatohepatitis, as assessed with the use of a
composite of standardized scores for steatosis, lobular inflammation,
hepatocellular ballooning, and fibrosis. Given the two planned primary
comparisons, P values of less than 0.025 were considered to indicate
statistical significance. RESULTS: Vitamin E therapy, as compared with
placebo, was associated with a significantly higher rate of
improvement in nonalcoholic steatohepatitis (43% vs. 19%, P=0.001),
but the difference in the rate of improvement with pioglitazone as
compared with placebo was not significant (34% and 19%, respectively;
P=0.04). Serum alanine and aspartate aminotransferase levels were
reduced with vitamin E and with pioglitazone, as compared with placebo
(P<0.001 for both comparisons), and both agents were associated with
reductions in hepatic steatosis (P=0.005 for vitamin E and P<0.001 for
pioglitazone) and lobular inflammation (P=0.02 for vitamin E and
P=0.004 for pioglitazone) but not with improvement in fibrosis scores
(P=0.24 for vitamin E and P=0.12 for pioglitazone). Subjects who
received pioglitazone gained more weight than did those who received
vitamin E or placebo; the rates of other side effects were similar
among the three groups. CONCLUSIONS: Vitamin E was superior to placebo
for the treatment of nonalcoholic steatohepatitis in adults without
diabetes. There was no benefit of pioglitazone over placebo for the
primary outcome; however, significant benefits of pioglitazone were
observed for some of the secondary outcomes. (ClinicalTrials.gov
number, NCT00063622.) 2010 Massachusetts Medical Society

Certainly looks like solid science to me. Data only a pharma shill
would dispute?
From: Steven Bornfeld on
john wrote:

(snip)

>
> * Taking 300 IU vitamin E per day reduces lung cancer by 61%. (Mahabir S,
> Schendel K, Dong YQ et al. Dietary alpha-, beta-, gamma- and
> delta-tocopherols in lung cancer risk. Int J Cancer. 2008 Sep
> 1;123(5):1173-80.) http://www.ncbi.nlm.nih.gov/pubmed/18546288


Google search terms "Vitamin E and lung cancer":


http://www.google.com/search?q=vitamin+e+and+lung+cancer&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a


>
From: Steven Bornfeld on
trigonometry1972(a)gmail.com | wrote:
>> Thanks--turns up some interesting papers. I'm willing to learn.
>
> Then you'll make good comments and push back
> with some thought not just "rejectionist rage."


I thought I just did.



>
>
>>
>>
>>> three glasses of wine and 40 miles on the
>>> bicycle doing real miles and real distance
>> I know whose wheel I won't be on during my next club ride.
>>
>> Steve
>>
>>> ...........................................................Trig
>
> It was the ride first and then the wine.


Much better.

S.
From: trigonometry1972 on
On May 27, 12:43 pm, Steven Bornfeld <bornfeldm...(a)dentaltwins.com>
wrote:
> trigonometry1...(a)gmail.com | wrote:
> >>         Thanks--turns up some interesting papers.  I'm willing to learn.
>
> > Then you'll make good comments and push back
> > with some thought not just "rejectionist rage."
>
>         I thought I just did.
>
>
>
> >>> three glasses of wine and 40 miles on the
> >>> bicycle doing real miles and real distance
> >>         I know whose wheel I won't be on during my next club ride.
>
> >> Steve
>
> >>> ...........................................................Trig
>
> > It was the ride first and then the wine.
>
>         Much better.
>
> S.

I was in part talking to Peter.
So don't take it too personally. I am not a huge
fan of popular press links though I am known
to use them now and then. And sometimes
the Sciencedaily articles will have a link to a
primary source unlike newspaper articles.

Shrug...................Trig
From: Peter B. on
<trigonometry1972(a)gmail.com> wrote in message
news:13382f33-6393-417d-b74a-acb129f21eff(a)a27g2000prj.googlegroups.com...
On May 27, 12:43 pm, Steven Bornfeld <bornfeldm...(a)dentaltwins.com>
wrote:
> trigonometry1...(a)gmail.com | wrote:
> >> Thanks--turns up some interesting papers. I'm willing to learn.
>
> > Then you'll make good comments and push back
> > with some thought not just "rejectionist rage."
>
> I thought I just did.
>
>
>
> >>> three glasses of wine and 40 miles on the
> >>> bicycle doing real miles and real distance
> >> I know whose wheel I won't be on during my next club ride.
>
> >> Steve
>
> >>> ...........................................................Trig
>
> > It was the ride first and then the wine.
>
> Much better.
>
> S.

I was in part talking to Peter.
So don't take it too personally. I am not a huge
fan of popular press links though I am known
to use them now and then. And sometimes
the Sciencedaily articles will have a link to a
primary source unlike newspaper articles.

Shrug...................Trig
=====================================
Steven, evidently he has me on his brain since I was nowhere in this thread
until a message ago.
Shame that, unrequited love? LOL

He's a sensitive older guy.